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There is truly nothing like it. Nothing remotely compares to this site. The community is phenomenal. The site is run extremely smoothly and well. Best site for avid baseball lovers.The Langlands classification for non-connected -adic groups II: Multiplicity one. Abstract: For a non-connected reductive -adic group, we prove that the Langlands subrepresentation appears with multiplicity one in the representation parabolically induced from the corresponding Langlands data.
References [Enhancements On Off] What's this? Ban and C. Jantzen, The Langlands classification for non-connected -adic groupsIsrael Journal of Mathematics, MR i [B-J2] D. Jantzen, Degenerate principal series for even-orthogonal groupspreprint. Bernstein and A.
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MR [B-W] A. Borel and N. MR j [G-K] S. Gelbart and A. Knapp, -indistinguishability and groups for the special linear groupAdvances in Mathematics 43 MR 83j [G-H] D.
Goldberg and R. MR [J] C. Jantzen, Duality and supports of induced representations for even-orthogonal groupspreprint. Magyar, Langlands classification for real Lie groups with reductive Lie algebraActa Applicandae Mathematicae 37 MR 96i [L] R.
MR 91e [S] A. Silberger, The Langlands quotient theorem for -adic groupsMathematische Annalen MR The lowland rice-producing areas of the world may be classified first by water regime: those with a reliable and controlled external supply of water and a drainage system, the irrigated ricelands, and those depending solely on rainfall and runoff, the rainfed lowlands.
The latter are diverse and range from drought-prone lands to those subjected to flooding in excess of several meters during the growing season. Rice production in these areas hasn't really benefited from the technological advances that were so successful for irrigated rice, yet hundreds of millions of Asia's poorest people depend upon the rainfed lowlands for their livelihood.
This paper presents a retionale for devoting resources to research for the rainfed environments of Asia, and examines the institutional context and the key constraints and opportunities for intervention. The research strategies directed towards increasing sustainable productivity in these areas are presented, including the unique challenges presented by environmental heterogeneity and variability.
This is a preview of subscription content, log in to check access. Rent this article via DeepDyve. Adkins, S. Google Scholar. Ahmed, H. In: Rainfed Lowland Rice. Physiology of Stress Tolerance. Akbar, M. In: Progress in Rainfed Lowland Rice, — Amin, R.
Biswas, S. Boojung, H. Phenology, biomass production and yield. Field Crops Research Accepted. Bulatao, R. Buresh, R. Soil Sci. Burford, J. India Chameides, W. ScienceKiran, Feza H. Background and aims: Risk factors for peristomal pyoderma gangrenosum PPG are not well defined. The aim of this study was to evaluate risk factors associated with development of PPG. The control group was selected by matching for underlying diseases and type of stoma in a ratio of Univariate and multivariate analyses were performed.
Results: A total of 15 PPG cases and 45 controls were included. The mean age at the time of PPG diagnosis was The underlying disease was Crohn's disease in 7 patients Eleven patients In multivariate analysis, female gender, the presence of concurrent autoimmune disorders, and a high body mass index BMI were significantly associated with the presence of PPG, with odds ratios of 8.
After a median follow-up of Pyoderma gangrenosum is an ulcerative, cutaneous condition, initially described in Fifty percent of cases are found to be associated with underlying systemic diseases, most commonly inflammatory bowel diseases IBDarthritis, polyarthritis and malignancy.
Cultures typically do not reveal pathogenic organisms, and histologic evaluation often demonstrates nonspecific inflammatory reaction characterized by dermal infiltration of neutrophils. Other etiologies can also result in peristomal ulceration, resembling PPG, such as stitch abscess, contact dermatitis, extension of underlying Crohn's disease CD and irritation from leaking feces.
All eligible patients were identified by searching the database using the ICD-9 codes from March to May Both paper charts and electronic medical records were carefully reviewed to exact patients' demographic information, clinicopathological variables and outcomes of PPG.
In this case-control study, a consecutive of 15 PPG patients were identified as cases.
Plant nutrient efficiency: A comparison of definitions and suggested improvement
The controls were selected by matching for underlying disease and type of stoma with a study to control ratio of In order qualify for the study, PPG patients needed to meet all the following inclusion criteria: 1 having peristomal ulcers caused by pyoderma gangrenosum; 2 having underlying IBD; and 3 regular follow up at our institution.
Patients whose peristomal ulcers were caused by other etiologies, such as stitch abscess and contact dermatitis, were excluded. Controls needed to meet all the following inclusion criteria: 1 having stoma; 2 being consistent with the matching criteria; and 3 regularly being followed up at our institution.
Patients with a history of pyoderma gangrenosum were excluded. As shown by a previous study from our institution, 18 the diagnosis of PPG has predominantly been clinical and based on a classic presentation of painful, undermined peristomal ulceration. Biopsy of the ulcers was performed for the purpose of exclusion. If the patient failed the first-line topical and systemic therapy, anti-TNF biological agents infliximab, adalimumab, or certilizumab pegol were used.
Demographic and clinical variables evaluated in the study included age at the diagnosis of IBD, age at stoma construction, duration of IBD, duration of stoma, body mass index BMIgender, history of smoking or, excessive alcohol use, type of IBD, type of stoma, family history of IBD, concurrent autoimmune disorders, extraintestinal manifestations EIMsignificant comorbidities, history of drug allergy, history of tonsillectomy, pre-operation use of immunosuppressives, pre-operation use of biologics, pre-operation high platelet counts, indication for surgery, stoma complications and activity of underlying IBD.Conventional whole body CYP2E1 knockout mice displayed protection against high-fat diet-induced weight gain, obesity, and hyperlipidemia with increased energy expenditure despite normal food intake and spontaneous locomotor activity.
In addition, the CYP2E1 knockout mice displayed a marked improvement in glucose tolerance on both normal chow and high-fat diets. Euglycemic-hyperinsulinemic clamps demonstrated a marked protection against high-fat diet-induced insulin resistance in CYP2E1 knockout mice, with enhanced adipose tissue glucose uptake and insulin suppression of hepatic glucose output. In parallel, adipose tissue was protected against high-fat diet-induced proinflammatory cytokine production.
Taken together, these data demonstrate that the CYP2E1 deletion protects mice against high-fat diet-induced insulin resistance with improved glucose homeostasis in vivo. The isoform E1 of the CYP2 subfamily CYP2E1 is the only member in humans, rats, and mice that catalyzes the bioactivation of several procarcinogens and protoxins and participates in drug metabolism 4 In addition to its ability to oxidize a variety of xenobiotic compounds, CYP2E1 is involved in the oxidation of several endogenous fatty acids, particularly hydroxylation of saturated fatty acids and epoxidation of unsaturated fatty acids 102026 Increased oxidative stress has also been implicated as a causative factor for insulin resistance, and multiple studies show increased levels of oxidative stress markers in diabetes and related conditions 3.
In diabetes, increased flux of free fatty acids and glucose is associated with an elevation of mitochondrial reactive oxygen species ROS and consequent increased oxidative stress Increased mitochondrial oxidative stress is associated with increased CYP2E1 levels in diabetic rats 27 and diabetic patients 33 However, since transgenic overexpression of CYP2E1 could result in nonphysiological induction of ROS and impairment of insulin signaling, CYP2E1-deficient mice were used to determine the role of this enzyme in the pathogenesis of insulin resistance and diabetes.
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All mice were maintained on a h light-dark cycle with free access to food and water, and protocols were performed in accordance with and approved by the Albert Einstein College of Medicine Institutional Animal Care and Use Committee. Blood samples were drawn at 0, 15, 30, 60, and min after injection for the determination of blood glucose Precision Xtra; Abbot, Bedford, MA.
The mice were then fasted for 5 h, and euglycemic-hyperinsulinemic EU clamps were conducted in conscious mice as previously described 243with minor modification. The 2-h EU clamp was conducted with a continuous infusion of human insulin 2. Insulin-stimulated whole body glucose metabolism was estimated using continuous infusion of [3- 3 H]glucose 0. To determine the rate of basal glucose turnover, [3- 3 H]glucose 0.
Blood samples were taken at 0 min and every 10 min from 80 to min through the carotid artery. To estimate basal muscle glucose uptake, 2-[ 14 C]DG glucose was infused with isotonic saline.
Body composition parameters that included total body weight, total water, and lean and fat mass were determined by quantitative nuclear magnetic resonance noninvasive imaging as described previously The time-dependent weight gain over a wk period is shown in Fig.
Body composition analysis showed that the increase in weight of the WT mice was primarily due to an increase in adipose tissue mass, with only small changes in lean mass and total body water content Fig. Blood glucose levels were measured by glucometer after 0, 15, 30, 60, and min.
Blood was then collected following a h fast, and plasma levels of triglycerides TG; A and free fatty acids FFA; B were determined as indicated under experimental procedures. Since typically WT mice on a chow diet have a glucose infusion rate of 0. A : plasma glucose during basal and last 30 min of EU clamps 2.
B : glucose infusion rate GIR necessary to maintain euglycemia. C : whole body glucose uptake was determined as [3- 3 H]glucose specific activity tracer infusion rate during EU clamp. To identify the peripheral tissues responsible for the increased insulin sensitivity of the CYP2E1KO on a HFD, we determined the insulin suppression of hepatic glucose output and adipose tissue and muscle glucose uptake Fig.In this study, the electrical properties of four different stages of mouse ovarian surface epithelial MOSE cells were investigated using contactless dielectrophoresis cDEP.
This study expands the work from our previous report describing for the first time the crossover frequency and cell specific membrane capacitance of different stages of cancer cells that are derived from the same cell line. The specific membrane capacitance increased as the stage of malignancy advanced from These differences could be the result of morphological variations due to changes in the cytoskeleton structure, specifically the decrease of the level of actin filaments in the cytoskeleton structure of the transformed MOSE cells.
Studying the electrical properties of MOSE cells provides important information as a first step to develop cancer-treatment techniques which could partially reverse the cytoskeleton disorganization of malignant cells to a morphology more similar to that of benign cells.
Ovarian cancer is the most common cause of death arising from gynecological malignancies and is one of the top causes of cancer-related deaths of women in United States and Europe.
Diagnosis and treatment of ovarian cancer in early stages has been hindered by the lack of syngeneic cell models to study this form of cancer at different stages and the inability to isolate early cancer cells from peritoneal fluid.
Addressing the lack of adequate cell models, Roberts et al. It has been shown that benign and cancerous cells are different in many aspects including proliferation, metabolism, cytoskeleton, and other functional categories. It has been reported previously that oral squamous cell carcinomas have distinctly different electrical properties than more normal keratinocyte populations, 7 primary normal keratinocytes, pre-cancerous, dysplastic cells, 8 and non-cancer-derived oral epithelial cells.
Dielectrophoresis DEPthe motion of a particle due to its polarization in the presence of a non-uniform electric field, 14 has been used to manipulate particles, including mixing, 15 separation, 161718 enrichment, 1920 detection, 21 and to investigate their specific electrical properties. Positive dielectrophoresis acts towards regions of high electric field gradient, while negative dielectrophoresis repels particles from the regions of high electric field gradient.
There is a frequency, known as crossover frequency, at which the dielectrophoretic force changes sign and the dielectrophoretic force is zero. Electrical properties of cells, such as specific membrane capacitance, can be calculated from their crossover frequency. Traditionally, the non-uniform electric fields necessary to induce dielectrophoresis are generated by patterning metal electrodes onto the bottom of a microfluidic channel. This eliminates direct contact between the sample and the electrodes, preventing bubble formation in the sample channel due to electrolysis, enhancing sterility, and diminishing the effects of electrochemical reactions occurring at the fluid-electrode interface.
This technique has recently been used to enrich a population of tumor initiating cells TICs from non-tumor initiating cells, 25 to isolate live cells from dead cells, 26 segregate cancer cells from erythrocytes, 27 and separate breast cancer cells from different cell lines based on their metastatic potential. Typically, ovarian cancers originate from surface epithelial cells of the ovary or fallopian tubes. In this study, the crossover frequency of different stages of cancer cells which are derived from the same cell line are reported for the first time.
Typically, the rotational ROT spectra using quadrapole interdigitated electrodes are used for finding the crossover frequency of cells. In this method, a population of cells deflects towards the top positive DEP or bottom negative DEP half of a microfluidic channel by altering the applied frequency.
The crossover frequency is found by observing the frequency at which no deflection occurs. We also investigated the specific membrane capacitance of MOSE cells as they progressed from benign to highly malignant stage.
We showed that the electrical properties of a cell are also affected by changes in morphology. This suggests that the cytoskeleton structure could be correlated with bioelectrical characteristics of ovarian cancer cells to provide a transformative approach for characterizing cell progression and phenotypic responses to treatment. Since the changes in electrical properties during progression are associated with the disease phenotype, by studying these changes the outcome of a treatment regimen that affects the cytoskeleton and membrane topography can be predicted.
Studying the electrical properties of MOSE cells provides important information as a first step to developing cancer-treatment techniques that could partially reverse the cytoskeleton disorganization of malignant cells to a morphology more similar to that of benign cells. The average DEP force acting on a spherical particle in a non-uniform electric field is given by There are numerous methods presented in the literature to model the CM factor of cells.
The complex permittivity of the cell is defined as a function of the complex permittivity of the membrane, memand cytoplasm, cyt :. For each cell type, within a specific media, there exists a unique frequency at which the cells and media have equivalent complex permittivity, known as the crossover frequency, f x o.
When suspended in a low conductivity media 0. The crossover frequency, f x ocan be found from Eq. The specific capacitance of the cell membrane, C m e mis. It has been shown that for mammalian cells, the second term is negligible considering the conductivity of the media 0. A top view schematic of the device is shown in Fig. Two symmetric electrode channels work as a source and the other electrode channel as a sink.Selection of plant cultivars tolerant of low nutrient supply may increase productivity on low fertility soils and reduce fertilizer requirements.
The concept of nutrient efficiency was evaluated using data from a study of differences in germplasm response to phosphorus P availability in white clover Trifolium repens L. Application of various criteria identified in the literature as measures of nutrient efficiency did not clarify differences between purportedly P efficient and inefficient germplasms. Differences may have resulted from factors other than efficient use of available P.
To reduce the confounding effects that other factors have on nutrient efficiency, we propose that equivalent yields of germplasms be demonstrated where nutrients are not limiting. Mechanisms that enable enhanced nutrient efficiency can be identified less ambiguously using this improved approach.
This is a preview of subscription content, log in to check access. Rent this article via DeepDyve. John Wiley and Sons, New York. Google Scholar.
In Crops as Enhancers of Nutrient Use. Academic Press, San Diego. Blair G L Nutrient efficiency-what do we really mean? P J Randall, E.The Adventure of the Beryl Coronet (Part 119)
Kluwer Academic Publishers, Dordrecht. Blair G J and Cordero S The phosphorus efficiency of three annual legumes. Plant and Soil 50, — Plant and Soil 73, — Plant and Soil67— Caradus J R Mechanisms improving nutrient use by crop and herbage legumes.
Clark R B Physiology of cereals for mineral nutrient uptake, use and efficiency.